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Table 2 Assocaition of reproductive factors with incident CVDs

From: Reproductive factors and risk of cardiovascular diseases and all-cause and cardiovascular mortality in American women: NHANES 2003–2018

Reproductive Factors

Age-Adjusted Model

Multivariable Model

OR (95% CI)

P Value

OR (95% CI)

P Value

≤ 11

1.55(0.03–1.89)

0.000

1.36(1.10–1.69)

0.005

12–13

ref

14–15

1.07(0.16–1.27)

0.447

1.06(0.89–1.27)

0.497

≥ 16

1.35(0.10–1.71)

0.016

1.26(1.00-1.59)

0.054

Age at menopause

≤ 44

1.84(0.90–2.22)

0.000

1.69(1.40–2.03)

0.000

35–49

ref

50–54

0.83(0.87–1.04)

0.102

0.93(0.73–1.18)

0.538

≥ 55

0.87(0.11–1.14)

0.316

0.93(0.71–1.22)

0.600

Reproductive lifespan

≤ 32

1.79(0.08–2.21)

0.000

1.63(1.33-2.00)

0.000

33–35

ref

36–38

0.92(0.79–1.21)

0.565

0.94(0.70–1.26)

0.660

39–41

0.80(0.03–1.10)

0.174

0.90(0.65–1.26)

0.540

≥ 42

0.97(0.11–1.26)

0.814

1.02(0.77–1.35)

0.904

Maternal age at first live birth

≤ 19

1.37(0.23–1.72)

0.006

1.04(0.81–1.33)

0.742

21–23

ref

24–26

0.67(0.97 − 0.94)

0.021

0.77(0.53–1.11)

0.159

≥ 27

0.50(0.11–0.69)

0.000

0.75(0.52–1.08)

0.123

Maternal age at last live birth

≤ 26

1.26(0.98–1.62)

0.066

1.08(0.85–1.37)

0.545

27–29

ref

30–34

0.90(0.70–1.16)

0.427

1.00(0.77–1.30)

0.979

35–39

0.95(0.72–1.26)

0.716

1.09(0.82–1.44)

0.561

≥ 40

1.39(0.87–2.22)

0.166

1.44(0.89–2.32)

0.135

Number of pregnancies

1

0.96(0.03–1.28)

0.793

1.00(0.74–1.34)

0.984

2

ref

3

0.89(0.17–1.13)

0.328

0.92(0.71–1.20)

0.551

4

1.21(0.21–1.58)

0.165

1.13(0.85–1.50)

0.393

≥ 5

1.52(0.10–1.84)

0.000

1.26(1.02–1.55)

0.034

Age at menarche

0.95(0.10–0.99)

0.017

0.95(0.91–1.01)

0.105

Age at menopause

0.95(0.11–0.96)

0.000

0.96(0.96–0.97)

0.000

Reproductive lifespan

0.96(0.11–0.96)

0.957

0.97(0.96–0.97)

0.000

Maternal age at first live birth

0.92(0.11–0.95)

0.000

0.97(0.95-1.00)

0.057

Maternal age at last live birth

0.99(0.11-1.00)

0.105

1.01(0.99–1.03)

0.520

Number of pregnancies

1.10(0.10–1.13)

0.000

1.06(1.02–1.09)

0.001