Reproductive Factors | Age-Adjusted Model | Multivariable Model | ||
---|---|---|---|---|
HR (95% CI) | P Value | HR (95% CI) | P Value | |
≤ 11 | 1.06(0.78–1.44) | 0.696 | 0.97(0.71–1.31) | 0.828 |
12–13 | ref | |||
14–15 | 1.11(0.82–1.51) | 0.488 | 1.00(0.75–1.34) | 0.989 |
≥ 16 | 1.31(0.91–1.88) | 0.141 | 1.14(0.81–1.60) | 0.463 |
Age at menopause | ||||
≤ 44 | 1.34(0.96–1.87) | 0.085 | 1.21(0.87–1.68) | 0.256 |
35–49 | ref | |||
50–54 | 0.91(0.67–1.24) | 0.562 | 0.94(0.68–1.28) | 0.677 |
≥ 55 | 0.80(0.54–1.18) | 0.260 | 0.81(0.53–1.22) | 0.309 |
Reproductive lifespan | ||||
≤ 32 | 1.73(1.21–2.49) | 0.003 | 1.62(1.10–2.39) | 0.014 |
33–35 | ref | |||
36–38 | 1.18(0.83–1.69) | 0.356 | 1.19(0.81–1.76) | 0.367 |
39–41 | 0.97(0.65–1.45) | 0.886 | 1.07(0.71–1.63) | 0.739 |
≥ 42 | 0.89(0.56–1.41) | 0.614 | 0.91(0.55–1.51) | 0.719 |
Maternal age at first live birth | ||||
≤ 19 | 2.19(1.55–3.09) | 0.000 | 1.63(1.10–2.41) | 0.015 |
21–23 | ref | |||
24–26 | 1.30(0.80–2.12) | 0.294 | 1.45(1.37–2.46) | 0.172 |
≥ 27 | 1.15(0.69–1.90) | 0.595 | 1.36(1.18–2.44) | 0.309 |
Maternal age at last live birth | ||||
≤ 26 | 1.21(0.69–2.10) | 0.504 | 1.11(0.64–1.92) | 0.709 |
27–29 | ref | |||
30–34 | 1.09(0.60–2.01) | 0.774 | 1.10(0.58–2.07) | 0.776 |
35–39 | 1.12(0.62-2.00) | 0.714 | 1.09(0.61–1.96) | 0.764 |
≥ 40 | 1.31(0.77–2.21) | 0.315 | 1.06(0.63–1.78) | 0.838 |
Number of fetation | ||||
1 | 1.44(0.89–2.32) | 0.134 | 1.60(0.97–2.63) | 0.067 |
2 | ref | |||
3 | 1.09(0.75–1.61) | 0.644 | 1.19(0.80–1.76) | 0.398 |
4 | 1.41(0.94–2.12) | 0.096 | 1.35(0.89–2.05) | 0.155 |
≥ 5 | 1.40(1.00-1.96) | 0.052 | 1.08(0.75–1.55) | 0.666 |
Age at menarche | 1.05(0.98–1.12) | 0.188 | 1.04(0.97–1.11) | 0.279 |
Age at menopause | 0.97(0.96–0.99) | 0.000 | 0.98(0.97–0.99) | 0.001 |
Reproductive lifespan | 0.97(0.96–0.98) | 0.000 | 0.98(0.97–0.99) | 0.000 |
Maternal age at first live birth | 0.95(0.91-1.00) | 0.031 | 1.00(0.95–1.05) | 0.976 |
Maternal age at last live birth | 0.98(0.95–1.02) | 0.363 | 0.99(0.96–1.02) | 0.470 |
Number of pregnancies | 1.02(0.98–1.07) | 0.328 | 0.96(0.91–1.02) | 0.209 |