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Table 1 Characteristics of the study sample at each checkup (N = 3632)

From: Trajectories of peripheral white blood cells count around the menopause: a prospective cohort study

Variables

1st Checkup (2006–2007)

2nd Checkup (2008–2009)

3rd Checkup (2010–2011)

4th Checkup (2012–2013)

5th Checkup (2014–2015)

6th Checkup (2016–2017)

7th Checkup (2018–2020)

Na

3339

2984

3151

2993

2703

2582

2483

Age at checkupb, y, mean (SD)

46.16 (4.10)

47.67 (4.58)

49.40 (4.68)

51.60 (4.68)

53.70 (4.75)

56.34 (4.56)

57.78 (4.45)

Education levelb, n (%)

       

 Junior high school or below

2310 (69.22)

1983 (66.45)

2103 (66.74)

1994 (66.62)

1804 (66.77)

1790 (69.35)

1650 (66.51)

 Senior high school or above

1027 (30.78)

1001 (33.55)

1048 (33.26)

999 (33.38)

898 (33.23)

791 (30.65)

831 (33.49)

 Missing

2

0

0

0

1

1

2

Smoking statusb, n (%)

       

 Never

3279 (98.20)

2928 (98.12)

3099 (98.35)

2945 (98.40)

2667 (98.67)

2546 (98.61)

2447 (98.55)

 Previous

15 (0.45)

15 (0.50)

12 (0.38)

12 (0.40)

9 (0.33)

8 (0.31)

9 (0.36)

 Current

45 (1.35)

41 (1.37)

40 (1.27)

36 (1.20)

27 (1.00)

28 (1.08)

27 (1.09)

Alcohol consumptionb, n (%)

       

 No

3104 (92.96)

2728 (91.54)

2973 (94.38)

2831 (94.75)

2549 (94.41)

2443 (94.84)

2336 (94.46)

 Occasional

224 (6.71)

240 (8.05)

169 (5.37)

143 (4.79)

139 (5.15)

121 (4.70)

129 (5.22)

 Often

11 (0.33)

12 (0.40)

8 (0.25)

14 (0.47)

12 (0.44)

12 (0.47)

8 (0.32)

 Missing

0

4

1

5

3

6

10

Physical activityb, n (%)

       

 Inactive

182 (5.47)

541 (18.19)

968 (30.78)

961 (32.21)

869 (32.20)

766 (29.83)

791 (32.00)

 Occasional

2828 (84.95)

1887 (63.45)

1767 (56.18)

1703 (57.07)

1556 (57.65)

1522 (59.27)

1426 (57.69)

 Active

319 (9.58)

546 (18.36)

410 (13.04)

320 (10.72)

274 (10.15)

280 (10.90)

255 (10.32)

 Missing

10

10

6

9

4

14

11

Diabetes history and anti-diabetic medicationb, n (%)

       

 No diabetes history

3164 (94.82)

2776 (93.06)

2888 (91.65)

2687 (89.93)

2367 (88.22)

2210 (85.76)

2079 (84.44)

 Diabetes history with no medication

131 (3.93)

112 (3.75)

168 (5.33)

204 (6.83)

215 (8.01)

268 (10.40)

262 (10.64)

 Diabetes history with medication

42 (1.26)

68 (2.28)

86 (2.73)

82 (2.74)

61 (2.27)

97 (3.76)

99 (4.02)

 Diabetes history with medication missing

0 (0)

27 (0.91)

9 (0.29)

15 (0.50)

40 (1.49)

2 (0.08)

22 (0.89)

 Missing

2

1

0

5

20

5

21

Hypertension history and anti-hypertensive medicationb, n (%)

       

 No hypertension history

2662 (79.77)

2201 (73.81)

2189 (69.47)

1951 (65.21)

1645 (61.15)

1453 (56.41)

1319 (53.34)

 Hypertension history with no medication

471 (14.11)

519 (17.40)

676 (21.45)

763 (25.50)

770 (28.62)

877 (34.05)

839 (33.93)

 Hypertension history with medication

154 (4.61)

204 (6.84)

274 (8.70)

256 (8.56)

189 (7.03)

241 (9.36)

247 (9.99)

 Hypertension history with medication missing

50 (1.50)

58 (1.95)

12 (0.38)

22 (0.74)

86 (3.20)

5 (0.19)

68 (2.75)

 Missing

2

2

0

1

13

6

10

Dyslipidemia history and lipid-lowering medicationb, n (%)

       

 No dyslipidemia history

2500 (74.87)

1981 (66.39)

1925 (61.09)

1633 (54.58)

1331 (49.30)

1148 (44.46)

973 (39.19)

 Dyslipidemia history with no medication

699 (20.93)

995 (33.34)

1199 (38.05)

1320 (44.12)

1298 (48.07)

1428 (55.31)

1387 (55.86)

 Dyslipidemia history with medication

10 (0.30)

8 (0.27)

27 (0.86)

17 (0.57)

13 (0.48)

6 (0.23)

48 (1.93)

 Dyslipidemia history with medication missing

130 (3.89)

0 (0)

0 (0)

22 (0.74)

58 (2.15)

0 (0)

75 (3.02)

 Missing

0

0

0

1

3

0

0

BMIb, kg/m2, mean (SD)

24.58 (3.39)

24.56 (3.35)

24.82 (3.36)

24.81 (3.30)

24.79 (3.24)

24.79 (3.35)

24.72 (3.42)

Hb, g/L, mean (SD)

132.75 (13.32)

129.46 (12.98)

133.58 (12.59)

134.60 (11.97)

135.87 (11.47)

136.06 (10.19)

136.25 (9.86)

  1. Abbreviations: SD, standard deviation; BMI, body mass index; Hb, hemoglobin
  2. a N is the number of women whose leukocyte values are available at each examination
  3. b Education level and smoking status were time-invariant variables, and the table showed the data at the first examination. Age at checkup, alcohol consumption, physical activity, hypertension history and anti-hypertensive medication, diabetes history and anti-diabetic medication, dyslipidemia history and lipid-lowering medication, BMI, and Hb were time-varying variables, and the table showed the data at each examination