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Table 2 Estimated annual changes in WBC indicators within each time segment in relation to the FMPa

From: Trajectories of peripheral white blood cells count around the menopause: a prospective cohort study

WBC indicators

Crude model

Adjusted model b

Obs. c

β (SE)

P Value

Obs. c

β (SE)

P Value

A vs. B

B vs. C

C vs. D

D vs. E

P Value d

P Value d

P Value d

P Value d

TWBC, ×109/L

Time segments relative to FMP

A. < -6 y relative to FMP

2,573

0.011(0.013)

0.4014

2,567

0.004(0.014)

0.7944

0.2084

0.0069

0.0325

0.0004

B. -6 ∼ -3 y relative to FMP

3,249

-0.013(0.014)

0.3433

3,222

-0.025(0.015)

0.0909

    

C. -3 ∼ 0 y relative to FMP

4,100

-0.060(0.012)

< 0.0001

4,065

-0.086(0.013)

< 0.0001

    

D. 0 ∼ + 2 y relative to FMP

2,617

-0.010(0.015)

0.4987

2,597

-0.035(0.016)

0.0256

    

E. > +2 y relative to FMP

7,586

0.030(0.004)

< 0.0001

7,428

0.025(0.007)

0.0004

    

NEUT, ×109/L

Time segments relative to FMP

A. < -5 y relative to FMP

3,543

0.011(0.009)

0.2026

3,526

0.014(0.010)

0.1546

0.3038

0.3102

< 0.0001

0.4063

B. -5 ∼ -4 y relative to FMP

1,061

-0.026(0.032)

0.4148

1,052

-0.024(0.031)

0.4446

    

C. -4 ∼ + 2 y relative to FMP

7,821

-0.050(0.005)

< 0.0001

7,753

-0.058(0.006)

< 0.0001

    

D. +2 ∼ + 6 y relative to FMP

4,254

0.003(0.006)

0.6794

4,194

0.005(0.008)

0.5375

    

E. > +6 y relative to FMP

3,197

0.009(0.008)

0.2286

3,110

0.015(0.009)

0.0828

    

LYM, ×109/L

Time segments relative to FMP

A. < -5 y relative to FMP

3,587

-0.019(0.006)

0.0009

3,570

-0.020(0.004)

< 0.0001

0.0563

0.0041

  

B. -5 ∼ -1 y relative to FMP

4,902

0.007(0.003)

0.0210

4,865

-0.010(0.004)

0.0087

    

C. > -1 y relative to FMP

11,578

0.012(0.001)

< 0.0001

11,387

0.001(0.003)

0.6530

    

MON, ×109/L

Time segments relative to FMP

A. < -4 y relative to FMP

4,584

-0.005(0.001)

< 0.0001

4,566

-0.006(0.001)

< 0.0001

0.8535

< 0.0001

  

B. -4 ∼ + 2 y relative to FMP

7,805

-0.003(0.001)

< 0.0001

7,736

-0.005(0.001)

< 0.0001

    

C. > +2 y relative to FMP

7,367

0.004(0.000)

< 0.0001

7,213

0.003(0.001)

< 0.0001

    
  1. Abbreviations: WBC, white blood cells; TWBC, total white blood cells; NEUT, neutrophils; LYM, lymphocytes; MON, monocytes; Obs., observations; FMP, final menstrual period
  2. a Women with at least 2 observations for a given inflammation marker were included for mixed-effect models
  3. b Adjusted for age at checkup (continuous), educational level, smoking status, alcohol consumption, physical activity, hypertension history and anti-hypertensive medication, diabetes history and anti-diabetic medication, dyslipidemia history and lipid-lowering medication, body mass index (continuous), and hemoglobin (continuous) as fixed effects
  4. c Number of observations used to build models
  5. dP value for pairwise difference in adjacent time segment slopes
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BMC Women's Health

ISSN: 1472-6874

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