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Table 4 Annual changes in WBC in relation to the FMP across baseline BMI subgroups a

From: Trajectories of peripheral white blood cells count around the menopause: a prospective cohort study

WBC indicators

Normal weight (BMI < 24 kg/m2)

Overweight (BMI 24  27.9 kg/m2)

Obesity (BMI ≥ 28 kg/m2)

Obs. b

β (SE)

P Value

Obs. b

β (SE)

P Value

Obs. b

β (SE)

P Value

TWBC, ×109 /L

        

Time segments relative to FMP

        

A. < -6 y relative to FMP

1,518

0.003(0.018)

0.8689

864

-0.011(0.025)

0.6504

273

0.013(0.046)

0.7747

B. -6 -3 y relative to FMP

1,658

-0.050(0.019)

0.0094

1,159

0.013(0.026)

0.6192

400

-0.027(0.040)

0.5122

C. -3  0 y relative to FMP

2,040

-0.087(0.018)

< 0.0001

1,547

-0.088(0.023)

0.0001

590

-0.070(0.039)

0.0731

D. 0  + 2 y relative to FMP

1,220

-0.022(0.021)

0.3049

938

-0.091(0.027)

0.0007

356

0.078(0.044)

0.0763

E. > +2 y relative to FMP

3,401

0.007(0.010)

0.4859

2,813

0.036(0.012)

0.0037

1,102

0.066(0.019)

0.0007

LYM, ×109/L

         

Time segments relative to FMP

A. < -5 y relative to FMP

2,021

-0.027(0.006)

< 0.0001

1,235

-0.020(0.008)

0.0098

391

0.004(0.014)

0.7609

B. -5 -1 y relative to FMP

2,471

-0.007(0.005)

0.1842

1,789

-0.011(0.006)

0.0976

657

-0.015(0.011)

0.1760

C. > -1 y relative to FMP

5,314

-0.004(0.004)

0.3466

4,276

0.000(0.005)

0.9901

1,668

0.026(0.007)

0.0005

MON, ×109/L

         

Time segments relative to FMP

A. < -4 y relative to FMP

2,547

-0.006(0.002)

< 0.0001

1,593

-0.003(0.002)

0.1637

510

-0.019(0.005)

0.0003

B. -4  + 2 y relative to FMP

3,804

-0.004(0.001)

0.0001

2,864

-0.008(0.001)

< 0.0001

1,095

-0.005(0.002)

0.0413

C. > +2 y relative to FMP

3,297

0.003(0.001)

0.0024

2,731

0.003(0.001)

0.0118

1,074

0.007(0.001)

0.0002

  1. Abbreviations: WBC, white blood cells; TWBC, total white blood cells; LYM, lymphocytes; MON, monocytes; Obs., observations; FMP, final menstrual period; BMI, body mass index
  2. a Participants were divided into three baseline BMI subgroups: Normal weight (BMI < 24 kg/m2), overweight (BMI 24  27.9 kg/m2), and obesity (BMI > = 28 kg/m2). Women with at least 2 measurements for a given lipid parameter were included for mixed-effect models. Models were adjusted for age at checkup (continuous), educational level, smoking status, alcohol consumption, physical activity, hypertension history and anti-hypertensive medication, diabetes history and anti-diabetic medication, dyslipidemia history and lipid-lowering medication, BMI (continuous), and hemoglobin (continuous) as fixed effects
  3. b Number of observations used to build models