Fig. 2

Primary analyses (IVW method) of the causal effect of neuroticism clusters on female reproductive diseases. Mendelian randomization estimates are presented as OR with corresponding 95% CI, which provide an estimate of the relative outcome risk caused by each standard-deviation increase in exposure. Abbreviation: CI, confidence interval; OR, odds ratio; PCOS, polycystic ovary syndrome; RSA, recurrent spontaneous abortion; SA, spontaneous abortion; SESA, sensitivity to environmental stress and adversity; SNP, single nucleotide polymorphism; UF, uterine fibroids