Fig. 3

Primary analyses (IVW method) of the causal effect of female reproductive diseases on neuroticism clusters. Mendelian randomization estimates are presented as Beta values with the corresponding 95% CI, which provide an estimate of the relative outcome risk caused by exposure. Abbreviation: CI, confidence interval; PCOS, polycystic ovary syndrome; SA, spontaneous abortion; SESA, sensitivity to environmental stress and adversity; SNP, single nucleotide polymorphism; UF, uterine fibroids