Causality between neuroticism personality clusters and female reproductive diseases in European population: a two-sample bidirectional mendelian randomization study

Table 2 Heterogeneity and horizontal pleiotropy for genetically causal effect of female reproductive diseases on neuroticism clusters

Exposure	Outcome	Horizontal pleiotropy		Heterogeneity (IVW method)
Exposure	Outcome	MR Egger_intercept	pval	Cochran’s Q	Q_pval
Infertility	Depressed	0.002	0.241	11.084	0.522
	Worry	0.001	0.620	10.989	0.530
	SESA	0.003	0.070	14.554	0.409
PCOS	Depressed	0.001	0.736	10.255	0.418
	Worry	0.001	0.756	6.673	0.671
	SESA	-0.001	0.748	5.281	0.872
SA	Depressed	-0.002	0.278	7.792	0.732
	Worry	-0.002	0.440	4.108	0.942
	SESA	-0.002	0.352	7.879	0.641
Endometriosis	Depressed	-0.004	0.067	22.399	0.319
	Worry	0.000	0.800	16.498	0.685
	SESA	-0.002	0.322	16.213	0.643
UF	Depressed	0.000	0.586	42.116	0.553
	Worry	0.000	0.870	41.226	0.461
	SESA	0.001	0.312	38.284	0.676

Abbreviation: IVW Inverse variance-weighted, PCOS Polycystic ovary syndrome, SA Spontaneous abortion, SESA Sensitivity to environmental stress and adversity, UF Uterine fibroids

ISSN: 1472-6874