Infertility treatments and risk of breast benign diseases: a case‒control study

BMC Women's Health

Table 2 Characteristics of previous infertility treatments

		No BBD (n = 104)	BBD (n = 50)	P-value
Total Infertility Treatments
History of previous infertility treatments ^a		64 (61.5)	33 (66)	0.591
Total number of infertility treatments cycles ^b		2.59 ± 2.39	3.52 ± 3.79	0.120
infertility treatments type ^a
	ART ^#	52 (81)	25 (76)	0.526
	OI ^‡	12 (19)	8 (24)
ART Treatments Characteristics
Total Number of ART cycles ^b		1.17 ± 1.30	1.44 ± 1.64	0.317
Last ART cycle ^a
	=< 1 year	24 (46)	12 (48)	0.809
	1–2 years	10 (19)	6 (24)
	>= 3 years	18 (35)	7 (28)
Lifetime Exogenous Hormone Therapy^†
Total courses of OI ^b		1.42 ± 1.72	2.08 ± 3.01	0.157
Total courses of hMG or FSH injection ^*		1.62 ± 1.05	1.56 ± 0.97	0.773
Progesterone use history ^b		61 (58.7)	33 (66)	0.381
Progesterone use duration (months) ^a		1.55 ± 2.56	1.95 ± 2.62	0.379
EV use history ^b		59 (56.7)	27 (54)	0.749
EV use duration (months) ^a		1.70 ± 4.07	1.72 ± 3.38	0.984
OCP use History ^b		54 (52)	26 (52)	0.993
OCP use duration (months) ^a		7.00 ± 17.84	7.88 ± 18.53	0.780

a: Data presented as ratio (%) and analysis were based on chi-squared; b: Data presented as the mean ± standard deviation and analysis were based on T test; # Including COS cycles (either inseminated by ICSI or IVF) and FET; ‡ Including OI by Clomiphene citrate or Letrozole that were followed either by natural insemination or combined with IUI; † This data is related to all forms of lifetime exogenous hormone therapy. This included OCP, EV, and progesterone, which were prescribed for a variety of clinical indications. These ranged from infertility treatment programs to endometrial preparation for frozen embryo transfer, cycle scheduling, and treatment of gynecological pathologies. * Includes history of all COS cycles that required courses of hMG or FSH injection. ART: Assisted reproductive techniques; CI: Confidence interval; COS: controlled ovarian stimulation; EV: estradiol Valerate; FET: Frozen-thawed embryo transfer; FSH: Follicle Stimulating Hormone; hMG: human Menopausal Gonadotropin; ICSI: Intracytoplasmic injection; IUI: intrauterine insemination; IVF: In vitro fertilization; OCP: oral contraceptive pills; OI: Ovulation induction; OR: odds ratio

ISSN: 1472-6874