Skip to main content

Table 2 Clinicopathological characteristics and adjuvant treatment of EECs with MELF pattern

From: Molecular classification and adjuvant treatment in endometrioid endometrial cancer with microcystic elongated and fragmented (MELF) invasion pattern

 

Total

(N = 84)

Surveillance (n = 15)

RT (n = 19)

CT ± RT (n = 50)

p-value

Age (years)

59.8 ± 8.27

61.3 ± 12.6

60.2 ± 8.7

59.3 ± 6.4

0.31

BMI (kg/m2)

25.9(24.1–28.4)

25.5(22.7–29.7)

25.5(24.6–26.9)

26.4(24.0-28.6)

0.57

TS (cm)

3.5 (2.5–4.8)

2.7 (1.5–3.5)

3.0 (2.5–4.5)

3.2(2.5-5.0)

0.71

Follow-up time

26 (12–41)

24 (6–43)

21(10–29)

29(14–45)

0.79

Molecular subtype

    

0.071

POLEmut

1

1(100%)

0

0

 

dMMR

19

3(16%)

7(37%)

9(47%)

 

NSMP

53

10(19%)

12(23%)

31(58%)

 

p53-abn

11

1(9%)

0

10(91%)

 

Stage

    

0.411

IA

35

9(26%)

10(28%)

16(46%)

 

IB

29

5(17%)

4(14%)

20(69%)

 

II

7

1(14%)

2(29%)

4(57%)

 

III

11

0

3(27%)

8(73%)

 

IV

2

0

0

2(100%)

 

Risk level

    

0.003

Low risk

18

8(45%)

6(33%)

4(22%)

 

Intermediate risk

11

3(27%)

2(18%)

6(55%)

 

High-intermediate risk

32

3(9%)

8(25%)

21(66%)

 

High risk

23

1(4%)

3(13%)

19(83%)

 

FIGO grade

    

0.383

G1

24

6(25%)

6(25%)

12(50%)

 

G2

47

9(19%)

10(21%)

28(60%)

 

G3

13

0

3(23%)

10(77%)

 

MI

    

0.144

≥ 1/2

43

9(22%)

12(29%)

20(49%)

 

<1/2

41

6(14%)

7(16%)

30(70%)

 

CSI

    

0.717

Present

10

14(19%)

16(22%)

44(59%)

 

Absent

74

1(10%)

3(30%)

6(60%)

 

LVSI

    

0.100

Present

42

11(26%)

10(24%)

21(50%)

 

Absent

42

4(10%)

9(21%)

29(69%)

 

LN

    

0.376

Metastasis

8

15(20%)

17(22%)

44(58%)

 

Normal

76

0

2(25%)

6(75%)

 
  1. Abbreviations: CT, chemotherapy; RT, radiotherapy; TS, tumor size; BMI, body mass index; MI, Myometrial Invasion; CSI, Cervical Stroma Involvement; LVSI, Lymphovascular Space Invasion; FIGO, Federation of International of Gynecologists and Obstetricians; LN, Lymph nodes