Table 2 Multivariable Cox regression for breast cancer-specific mortality and overall mortality associated with different hormone receptor statuses (only statistically significant results are shown in bold)

Time Period

2000–2009

1

Ref

1

Ref

1

Ref

1

Ref

2010–2019

0.83 (0.71–0.97)

0.021

0.83 (0.69–1.00)

0.045

0.9 (0.66–1.24)

0.525

0.87 (0.61–1.24)

0.428

Age

< 50

1

Ref

1

Ref

1

Ref

1

Ref

≥ 50

1.50 (1.21–1.88)

< 0.001

1.33 (1.06–1.68)

0.016

1.60 (1.05–2.42)

0.027

1.52 (0.97–2.37)

0.066

Race/Ethnicity

Black

1

Ref

1

Ref

1

Ref

1

Ref

White

0.80 (0.65–1.00)

0.049

0.76 (0.59–0.97)

0.027

0.74 (0.50–1.10)

0.136

0.68 (0.44–1.06)

0.086

Hispanic

0.80 (0.58–1.08)

0.149

0.73 (0.52–1.03)

0.073

0.74 (0.41–1.32)

0.309

0.74 (0.39–1.39)

0.352

Other

0.76 (0.52–1.12)

0.173

0.70 (0.45–1.09)

0.113

0.53 (0.28–1.04)

0.063

0.56 (0.27–1.14)

0.111

T Stage

T0&T1

1

Ref

1

Ref

1

Ref

1

Ref

T2

1.57 (1.20–2.06)

0.001

1.65 (1.18–2.31)

0.003

2.47 (1.51–4.02)

< 0.001

3.21 (1.70–6.06)

< 0.001

T3

3.94 (2.94–5.28)

< 0.001

4.83 (3.37–6.90)

< 0.001

3.91 (2.22–6.87)

< 0.001

5.22 (2.58–10.59)

< 0.001

T4

5.51 (3.94–7.70)

< 0.001

7.08 (4.78–10.49)

< 0.001

7.04 (3.92–12.63)

< 0.001

9.72 (4.69–20.14)

< 0.001

Node Status

Negative

1

Ref

1

Ref

1

Ref

1

Ref

Positive

2.00 (1.66–2.41)

< 0.001

2.23 (1.82–2.74)

< 0.001

2.22 (1.57–3.13)

< 0.001

2.27 (1.56–3.32)

< 0.001

Unknown

2.07 (1.59–2.68)

< 0.001

1.76 (1.25–2.48)

0.001

2.57 (1.63–4.05)

< 0.001

1.70 (0.95–3.06)

0.076

Surgery Type

BCS

1

Ref

1

Ref

1

Ref

1

Ref

Mastectomy

1.39 (1.13–1.71)

0.002

1.32 (1.04–1.68)

0.024

1.31 (0.88–1.94)

0.180

1.27 (0.80–2.00)

0.311

Radiotherapy

No/Unknown

1

Ref

1

Ref

1

Ref

1

Ref

Yes

0.72 (0.60–0.86)

< 0.001

0.70 (0.58–0.86

0.001

0.70 (0.48–1.02)

0.062

0.67 (0.44–1.02)

0.059

Chemotherapy

No/Unknown

1

Ref

1

Ref

1

Ref

1

Ref

Yes

0.63 (0.52–0.75)

< 0.001

NA^b

NA

0.55 (0.38–0.79)

0.001

0.70 (0.46–1.06)

0.093