Clinical characteristics and risk factors to high-grade vaginal intraepithelial neoplasia: a single-institution study

Table 2 HPV genotypes in high-grade CIN and high‐grade VaIN (n = 1819)

HPV infection	Single HPV infection,No. (%)		P-value	Multiple HPV infection,No. (%)		P-value	Total, No. (%)
HPV infection	high-grade CIN	high-grade VaIN	P-value	high-grade CIN	high-grade VaIN	P-value	Total, No. (%)
High risk
HPV16	402 (24.1)	34 (22.1)	0.566	247(14.8)	22 (14.3)	0.854	705 (38.8)
HPV18	67 (4)	5 (3.2)	0.636	80 (4.8)	6 (3.9)	0.611	158 ( 8.7)
HPV31	25 (1.5)	1 (0.6)	0.719	36 (2.2)	0 (0)	0.068	62 ( 3.4)
HPV33	57 (3.4)	5 (3.2)	0.908	60 (3.6)	8 (5.2)	0.319	130 ( 7.1)
HPV35	6 (0.4)	1 (0.6)	0.462	21 (1.3)	1 (0.6)	1	29 ( 1.6)
HPV39	15 (0.9)	1 (0.6)	1	47 (2.8)	5 (3.2)	0.798	68 ( 3.7)
HPV45	5 (0.3)	0 (0)	1	16 (1)	3 (1.9)	0.213	24 ( 1.3)
HPV51	29 (1.7)	3 (1.9)	0.749	62 (3.7)	12 (7.8)	0.014	106 ( 5.8)
HPV52	254 (15.3)	10 (6.5)	0.003	231(13.9)	20 (13)	0.76	515 (28.3)
HPV56	16 (1)	4 (2.6)	0.082	48 (2.9)	8 (5.2)	0.136	74 ( 4.1)
HPV58	160 (9.6)	18 (11.7)	0.406	145 (8.7)	18 (11.7)	0.216	341 (18.7)
HPV59	6 (0.4)	3 (1.9)	0.034	23 (1.4)	4 (2.6)	0.28	36 ( 2.0)
HPV66	9 (0.5)	0 (0)	1	32 (1.9)	4 (2.6)	0.54	45 ( 2.5)
HPV68	12 (0.7)	0 (0)	0.615	49 (2.9)	6 (3.9)	0.461	67 ( 3.7)
Low risk
HPV6	1 (0.1)	0 (0)	1	17 (1)	2 (1.3)	0.672	20 ( 1.1)
HPV11	0	0	0	13 (0.8)	1 (0.6)	1	16 ( 0.9)
HPV42	2 (0.1)	0 (0)	1	39 (2.3)	5 (3.2)	0.415	46 ( 2.5)
HPV43	1 (0.1)	0 (0)	1	15 (0.9)	3 (1.9)	0.191	19 ( 1.0)
HPV44	3 (0.2)	1 (0.6)	0.298	24 (1.4)	5 (3.2)	0.092	33 ( 1.8)
Other type
HPV53	5 (0.3)	1 (0.6)	0.412	59 (3.5)	9 (5.8)	0.15	74 ( 4.1)
HPV73	0	0	0	4 (0.2)	0 (0)	1	4 ( 0.2)
HPV82	1 (0.1)	0 (0)	1	6 (0.4)	0 (0)	1	7 ( 0.4)
HPVCP8304	5 (0.3)	1 (0.6)	0.412	32 (1.9)	11 (7.1)	< 0.001	49 ( 2.7)

Data are expressed as number of events (percentage)
Abbreviations: HPV human papillomavirus, VaIN vaginal intraepithelial neoplasia, CIN cervical intraepithelial neoplasia
Note: p values which are less than 0.05 are shown in bold

ISSN: 1472-6874