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Table 1 Patient characteristics in the study

From: Construction and validation of a novel nomogram for prediction of lymph node metastasis in HER2-positive breast cancer: based on the optimal number of examined lymph nodes for accurate nodal staging

Characteristic

Overall

N = 4,040

Training

N = 2,828

Validation set

N = 1,212

p-value

Age, n (%)

   

0.11

 < 59

1,980 (49.0%)

1,363 (48.2%)

617 (50.9%)

 

 >=59

2,060 (51.0%)

1,465 (51.8%)

595 (49.1%)

 

Race, n (%)

   

0.24

 Black

490 (12.1%)

352 (12.4%)

138 (11.4%)

 

 Other

495 (12.3%)

332 (11.7%)

163 (13.4%)

 

 White

3,055 (75.6%)

2,144 (75.8%)

911 (75.2%)

 

Radiation, n (%)

   

0.033

 No/Unknown

2,596 (64.3%)

1,847 (65.3%)

749 (61.8%)

 

 Yes

1,444 (35.7%)

981 (34.7%)

463 (38.2%)

 

Chemotherapy, n (%)

   

0.18

No/Unknown

1,129 (27.9%)

808 (28.6%)

321 (26.5%)

 

Yes

2,911 (72.1%)

2,020 (71.4%)

891 (73.5%)

 

T stage, n (%)

   

0.57

 T1

1,424 (35.2%)

1,008 (35.6%)

416 (34.3%)

 

 T2

1,974 (48.9%)

1,385 (49.0%)

589 (48.6%)

 

 T3

459 (11.4%)

310 (11.0%)

149 (12.3%)

 

 T4

183 (4.5%)

125 (4.4%)

58 (4.8%)

 

N stage, n (%)

   

0.007

 N0

1,213 (30.0%)

856 (30.3%)

357 (29.5%)

 

 N1

1,561 (38.6%)

1,119 (39.6%)

442 (36.5%)

 

 N2

769 (19.0%)

499 (17.6%)

270 (22.3%)

 

 N3

497 (12.3%)

354 (12.5%)

143 (11.8%)

 

ER, n (%)

   

0.55

 Negative

1,361 (33.7%)

961 (34.0%)

400 (33.0%)

 

 Positive

2,679 (66.3%)

1,867 (66.0%)

812 (67.0%)

 

PR, n (%)

   

0.11

 Negative

2,054 (50.8%)

1,461 (51.7%)

593 (48.9%)

 

 Positive

1,986 (49.2%)

1,367 (48.3%)

619 (51.1%)

 

Grade, n (%)

   

0.32

 I

147 (3.6%)

94 (3.3%)

53 (4.4%)

 

 II

1,243 (30.8%)

871 (30.8%)

372 (30.7%)

 

 III

2,643 (65.4%)

1,859 (65.7%)

784 (64.7%)

 

 IV

7 (0.2%)

4 (0.1%)

3 (0.2%)

 
  1. Note: ER, estrogen receptor; PR, progesterone receptor