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Table 1 Treatment patterns among a prospective cohort of Malawian women with breast cancer, December 2016-October 2018, by stage at presentation

From: Real-world breast cancer treatment patterns and guideline-concordant treatment completion among Malawian women

 

Stage II

Stage III

Stage IV

n = 13

n = 54

n = 24

Overall Treatment Combinations:

   

No Treatment

1 (4)

3 (5)

1 (4)

Surgery alone

0 (0)

2 (4)

0 (0)

Chemotherapy Alone

1 (4)

20 (36)

23 (96)

Surgery and chemotherapy

11 (92)

29 (54)

0 (0)

Underwent Surgery as Modified Radical Mastectomy

11 (92)

31 (57)

0 (0)

Type of chemotherapy:

n = 12#

n = 49#

n = 23#

Neoadjuvant alone, n (%)

1 (8)

22 (45)

--

Median number of cycles n (IQR)

6 (-)

3 (2–4)

 

Adjuvant alone, n (%)

5 (42)

7 (13)

--

Median number of cycles n (IQR)

6 (5–9)

6 (4–6)

 

Neoadjuvant and Adjuvant, n (%)

6 (50)

18 (33)

--

Median number of cycles n (IQR)

8 (7–9)

11 (10–13)

 

Palliative, n (%)

0 (0)

2 (7)

23 (100)

Median number of cycles n (IQR)

0 (0)

11 (9–12)

3 (1–9)

First chemotherapy regimen n (%)

n = 12#

n = 49#

n = 23#

AC 9 (75)

T 13 (27)

Doc/Plat 8 (35)

T 2 (17)

AC 11 (22)

T 7 (30)

CAF 1 (8)

TAC 4 (8)

CAF 2 (9)

 

CAF 4 (8)

CMF 2 (9)

 

CMF 4 (8)

Other 4 (17)

 

TC 2 (4)

 
 

Other 11 (22)

 

Type of Neoadjuvant Chemotherapy Received:

n = 7

n = 40

 

Anthracycline

5 (71)

22 (55)

Taxane

1 (14)

12 (30)

Anthracycline + Taxane

1 (14)

5 (13)

Other

0 (0)

1 (2)

Initiated endocrine therapy (ever) if Hormone Receptor Positive n (%)

n = 10^

n = 18^

n = 13^

3 (30)

8 (44)

4 (31)%

  1. #n is based on the number of patients who received chemotherapy (the sum of patients who received chemotherapy alone or surgery and chemotherapy)
  2. ^n for endocrine therapy is based on number of patients with hormone receptor positive disease (see Table 2)
  3. %Endocrine therapy may not be indicated for all patients with Stage IV hormone receptor positive disease
  4. AC = Doxorubicin, Cyclophosphamide
  5. TAC = Docetaxel, Cyclophosphamide, Doxorubicin
  6. T = Paclitaxel
  7. TC = Docetaxel, Cyclophosphamide
  8. Doc/Plat = Docetaxel, Carboplatin or Cisplatin
  9. CAF = Cyclophosphamide, Doxorubicin, Fluorouracil
  10. CMF = Cyclophosphamide, Methotrexate, Fluorouracil