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Table 2 Clinical characteristics of RA patients with early menopause before and after matching

From: Early menopause is associated with higher disease activity independent of inflammation in postmenopausal-onset rheumatoid arthritis

Characteristics

Before matching

 

After matching*

Usual menopause

(n = 459)

Early menopause

(n = 98)

P

Usual menopause

(n = 294)

Early menopause

(n = 98)

P

Age, years

61.2 ± 7.3

57.8 ± 9.7

0.001

 

61.9 ± 7.8

57.8 ± 9.7

< 0.001

Onset age, years

52.9 ± 10.2

47.3 ± 12.4

< 0.001

 

51.6 ± 10.9

47.3 ± 12.4

0.001

Menopause age, years

50.5 ± 2.5

42.2 ± 3.1

< 0.001

 

50.4 ± 2.5

42.2 ± 3.1

< 0.001

BMI, kg/m2

22.3 ± 3.3

22.2 ± 3.7

0.863

 

22.2 ± 3.2

22.2 ± 3.7

0.913

Disease duration, months

71 (24,132)

110 (41,181)

0.011

 

108 (42,177)

110 (41,181)

0.978

Active smoking, n (%)

21 (4.6)

7 (7.1)

0.307

 

13 (4.4)

7 (7.1)

0.486

Positive RF, n (%)

309 (67.6)

74 (75.5)

0.125

 

208 (71.0)

74 (75.5)

0.388

Positive ACPA, n (%)

311 (67.9)

68 (69.4)

0.775

 

203 (69.0)

68 (69.4)

0.950

CDAI

13 (6,24)

18 (9,32)

0.006

 

14 (6,28)

18 (9,32)

0.019

PROs

       

 PtGA

4 (2,6)

5 (2,7)

0.004

 

4 (2,6)

5 (2,7)

0.021

 Pain VAS

3 (2,5)

4 (2,6)

0.021

 

3 (2,5)

4 (2,6)

0.037

 HAQ-DI

0.3 (0,1.1)

0.8 (0.1,1.5)

0.016

 

0.5 (0,1.3)

0.8 (0.1,1.5)

0.018

PROs-associated indicators

       

 TJC28

3 (1,8)

5 (1,13)

0.040

 

3 (1,9)

5 (1,13)

0.060

 PrGA

3 (2,6)

4 (2,6)

0.005

 

4 (2,6)

4 (2,6)

0.020

SJC28

2 (0,5)

2 (0,7)

0.149

 

2 (0,5)

2 (0,7)

0.242

Inflammatory makers

       

 ESR, (mm/h)

41 (23,67)

53 (24,98)

0.061

 

42 (25,66)

53 (24,98)

0.119

 CRP, (mg/L)

5.0 (3.3,20.6)

12.1 (3.3,34.6)

0.021

 

5.3 (3.3,21.5)

12.1 (3.3,34.6)

0.041

Radiographic assessment

       

 mTSS

11 (5,51)

17 (7,49.9)

0.370

 

14 (6,58)

17 (7,49.9)

0.919

 JSN

4 (0,19)

5 (1,23)

0.429

 

6 (1,29)

5 (1,23)

0.724

 JE

7 (3,28)

11 (4,28)

0.398

 

9 (4,33)

11 (4,28)

0.966

  1. * matching disease duration 3:1
  2. RA, rheumatoid arthritis; RF, rheumatoid factor; ACPA, anti-cyclic citrullinated peptide antibody; PROs, patient-reported outcomes; PtGA, patient global assessment of disease activity; Pain VAS, pain visual analogue scale; HAQ-DI, Health Assessment Questionnaire Disability Index; TJC28, 28-joint tender joint counts; PrGA, provider global assessment of disease activity; SJC28, 28-joint swollen joint counts; CDAI, Clinical Disease Activity Index; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; mTSS, modified total Sharp score; JSN, joint space narrowing; JE, joint erosion
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BMC Women's Health

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