Expression of inflammatory states in response to psychological distress in breast cancer survivors and its relationship to subjective memory function complaints

Table 2 Results of cognitive function scale scores, cytokines, and inflammatory indicators in two groups of BC patients

Variables	PD(n = 53)	NPD(n = 51)	z^#	p
Cognitive Scale Scores
MMSE	21.62 ± 3.05	22.59 ± 2.50	-1.882	0.060
RM	18.85 ± 1.99	17.29 ± 2.41	-3.370	0.001
PM	19.94 ± 2.86	18.67 ± 3.17	-1.967	0.049
Cytokines Levels (pg/ml)
IL-1β	67.15 ± 35.18	56.04 ± 24.79	-2.920	0.004
TNF-α	65.48 ± 36.27	58.85 ± 20.58	-0.481	0.630
IL-4	41.96 ± 25.04	39.12 ± 16.25	-0.579	0.593
Markers of Systemic Inflammation Levels
NLR	2.91 ± 1.16	2.41 ± 1.01	-2.585	0.010
PLR	165.75 ± 67.94	143.49 ± 51.67	-1.460	0.144
MLR	0.33 ± 0.15	0.32 ± 0.13	-0.211	0.833
GLR	3.07 ± 1.17	2.51 ± 1.02	-2.858	0.004
SII	591.77 ± 264.68	473.91 ± 273.88	-2.747	0.006

Abbreviations: NPD, non-psychological distress; PD, psychological distress; MMSE, Mini‐Mental State Examination; RM, retrospective memory; PM, prospective memory; IL‐1β, interleukin‐1 beta; TNF‐α, tumor necrosis factor‐alpha; IL-4, interleukin‐4; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; GLR, granulocyte-to-lymphocyte ratio; SII, systemic immune-inflammation index
^#Mann–Whitney U test

ISSN: 1472-6874