Table 2 Screening Performance of TruScreen and Pap Smear
From: Cervical cancer screening: a comparative study of TruScreen vs. Pap Smear
Statistic | TruScreen | Pap smear | Combined Pap + Trusscreen | P-value* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | No/total | Value | 95% CI | No/total | Value | 95% CI | No/total | Value | 95% CI | Â |
Detection of abnormal cases (n = 6) |  | |||||||||
 Sensitivity | 5/6 | 83.3% | 35.9% to 99.6% | 4/6 | 66.7% | 22.3% to 95.7% | 6/6 | 100% | 54.1% to 100.0% | 0.910# |
 Specificity | 476/501 | 95% | 92.7% to 96.8% | 492/501 | 98.2% | 96.6% to 99.2% | 500/501 | 99.80% | 98.89% to 99.99% | |
 Positive Predictive Value | 5/5 | 100% | 54.1% to 100.0% | 4/4 | 100% | 54.1% to 100% | 5/5 | 100% | 54.1% to 100.0% | |
 Negative Predictive Value | 467/467 | 100% | 54.1% to 100.0% | 492/492 | 100% | 54.1% to 100% | 500/500 | 100% | 54.1% to 100% | |
Detection of CIN I (n = 3) |  | |||||||||
 Sensitivity | 2/3 | 66.7% | 12.5–98% | 2/3 | 66.7% | 12.5–98% | 3/3 | 100% | 54.1% to 100% | –- |
 Specificity | 476/498 | 95.6% | 93.4% to 97.2% | 492/501 | 98.2% | 96.6% to 99.2% | 500/501 | 99.80% | 98.89% to 99.99% | |
 Positive Predictive Value | 2/2 | 100% | 20.0–100% | 2/2 | 100% | 20–100% | 3/3 | 100% | 54.1% to 100.0% | |
 Negative Predictive Value | 467/467 | 100% | 54.1% to 100% | 492/492 | 100% | 54.07% to 100% | 500/500 | 100% | 54.1% to 100% | |
CIN II + (n = 2) |  | |||||||||
 Sensitivity | 2/2 | 100% | 15.81% to 100% | 2/2 | 100% | 15.8% to 100% | 2/2 | 100% | 54.1% to 100% | –- |
 Specificity | 476/499 | 95.3% | 93.2% to 97.1% | 492/499 | 98.6% | 97.1% to 99.4% | 500/501 | 99.80% | 98.89% to 99.99% | |
 Positive Predictive Value | 1/1 | 100% | 15.8% to 100% | 1/1 | 100% | 15.8% to 100% | 2/2 | 100% | 54.1% to 100.0% | |
 Negative Predictive Value | 467/467 | 100% | 54.07% to 100% | 492/492 | 100% | 54.07% to 100% | 500/500 | 100% | 54.1% to 100% | |
Glandular hyperplasia (n = 1) |  | |||||||||
 Sensitivity | 1/1 | 100% | 5.5 to 100% | 0/1 | 0% | 0 to 94% | 1/1 | 100% | 54.1% to 100% | 0.761 |
 Specificity | 476/500 | 95.2% | 92.9% to 96.9% | 492/500 | 98.4% | 96.8% to 99.3% | 500/501 | 99.80% | 98.89% to 99.99% | |
 Positive Predictive Value | 1/1 | 100% | 5.5 to 100% | 0/1 | 0% | 0 to 94% | 1/1 | 100% | 54.1% to 100.0% | |
 Negative Predictive Value | 467/467 | 100% | 54.1% to 100.0% | 492/492 | 100% | 54.1% to 100% | 500/500 | 100% | 54.1% to 100% | |