MCT-modified ketogenic diet as an adjunct to standard treatment regimen could alleviate clinical symptoms in women with endometriosis

Table 3 Biochemical parameters of the study subjects at baseline and after the 12-weeks of intervention

parameter	Time	Groups		Mean difference	95% CI		P^*
parameter	Time	MCT-modified KD (n = 19)	Control (n = 25)	Mean difference	Lower	Upper	P^*
AST	Before	18 (17, 24)	19 (16, 24)	1.6	−1.9	5.2	0.82^c
	After	18 (16, 21)	19 (17, 22)	0.8	−0.13	1.73	0.09^b
	Change	−1 (−3, 0)	0 (−3, 0)	0.31	−1.1	1.8	0.53^c
	P-within^**	0.02^e	0.03^e
ALT	Before	19.7 ± 6.7	17.8 ± 7.1	−1.8	−6.1	2.3	0.37^a
	After	18.9 ± 6	17.6 ± 6.1	0.14	−1.02	1.32	0.8^b
	Change	−0.84 ± 2.5	−0.28 ± 2.03	0.56	−0.87	1.9	0.43^a
	P-within^**	0.16^d	0.49^d
TG	Before	111 ± 36	100 ± 42	−11.5	−35.07	12.03	0.32^a
	After	109 ± 36	102 ± 35	2.9	−2.2	8.2	0.25^b
	Change	−2.2 ± 8.3	2.36 ± 10.4	4.57	−1.16	10.3	0.11^a
	P-within^**	0.26^d	0.27^d
TC	Before	143 ± 30	171 ± 26	27.8	10.58	45.11	0.02^a
	After	147 ± 28	164 ± 21	−3	−12.05	6.04	0.5^b
	Change	3.7 ± 17.7	−6.3 ± 11.7	−10.1	−19.7	−0.48	0.04^a
	P-within^**	0.36^d	0.01^d
HDL	Before	52 ± 14	53 ± 12	1.05	−7.1	9.2	0.79^a
	After	52 ± 12	54 ± 12	0.66	−1.5	2.8	0.55^b
	Change	0.05 ± 5.2	0.6 ± 2.8	0.54	−2.17	3.23	0.68^a
	P-within^**	0.96^d	0.3^d
LDL	Before	101 ± 22	95 ± 23	−6.8	−20.69	7.06	0.32^a
	After	107 ± 27	96 ± 17	−4.9	−11.05	1.08	0.1^b
	Change	5.58 ± 12.5	1.32 ± 7.93	−4.2	−10.81	2.29	0.19^a
	P-within^**	0.06^d	0.41^d

Data are presented as mean ± standard deviation or Median (IQR)
ALT alanine aminotransferase, AST aspartate aminotransferase, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TC total cholesterol, KD ketogenic diet
^*based on ^aindependent sample t test, ^cmann-whithney, and ^bgeneral linear model adjusted for baseline values and weight changes
^**based on ^dpaired sample T test or ^eWilcoxon

ISSN: 1472-6874